A wreath-laying ceremony was held Monday at the site of the fire on East 23rd Street in Manhattan - the deadliest day in the department's history until 9/11.
Nigro paid tribute to "the heroes of that awful day and the families they left behind."
The FDNY Foundation is launching the 23rd Street Fire Legacy Fund in their honor.
WATCH VIDEO FROM 1966 OF THE 23RD STREET FIRE
The fire on Oct. 17, 1966 began in an art store cellar. Firefighters were trying to reach it through the smoke-filled drugstore next door when the floor caved in.
A high-rise apartment building now occupies the site.
The department lost 343 members on Sept. 11, 2001. null