The crash happened in the southbound lanes of I-91 near exit 21 in Middletown.
Connecticut State Police said the crash involved at least 20 cars, 3 tractor trailers and a tanker truck. No serious injuries were reported.
(Flip through the gallery above to see more photos of the crash scene)
Troopers posted this video of the scene on social media:
Interstate 91 south was shut down between exit 21 and exit 25 for more than five hours.
The state police reported multiple crashes and spin-outs across the state.