Police will ask crowds to disperse, potentially issue summonses, and even arrest those not following the mandates.
The shutdown is back in parts Brooklyn and Queens in New York City, as well as Rockland, Orange, Nassau and Broome counties.
Related: Red, Orange, Yellow: Here are New York's new COVID cluster zones
And for those in the red zones, it means non-essential businesses have to close, restaurants can only offer takeout, there are no mass gatherings, and religious services capped at 10 people.
"It is ultimately all about each and every one of us, so folks in the red zone, in particular red zones, orange and yellow as well, is so much about what you do," Mayor Bill de Blasio said. "(It's) wearing masks, social distancing, it's all the basics that are that are going to help us come back."
The governor's order that came down earlier this week as the state tries to tackle alarming positive coronavirus rates in hotspots.
It's also the reason dozens took to the streets, rioting in Borough Park this week.
Many were unmasked, as the protested in response to the NYPD saying they'll be out educating -- but then conducting enforcement for those who don't comply.
RELATED: Fiery protest over NYC COVID cluster restrictions
The action also prompted one Orthodox Jewish organization and the Catholic Diocese of Brooklyn to sue the state.
The restrictions will be in place for at least two weeks, and it will be up to the math whether the areas can reopen.
You can find your zone at NYC.gov/covidzone.
ALSO READ: Frustration over closed parks causes protesters to cut locks to Brooklyn playground
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