Officials say the fire broke out on the fourth floor of a six-story building on West 120th Street in East Harlem around 9:15 a.m.
More than 130 firefighters and EMS members reported to the scene.
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Officials say the fire went to a third alarm just before 10 a.m.
They say several residents were injured and taken to the hospital.
There's no word yet on their condition.
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Two firefighters were taken to Cornell Medical Center for minor injuries.
The scene remains active.
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